Novel acyclic binuclear copper(II) and nickel(II) complexes were synthesized and characterized by spectroscopic methods. Cyclic voltammogram of all the complexes 1-4 were recorded in the cathodic potential range 0 to -1.4 V. All the copper (II) and nickel(II) complexes exhibit two quasi-reversible steps at different potentials. In competitive binding experiments the Kapp values for complexes were 3.1x105 M-1(1) 4.2x105 M-1(2), 3.78x105 M-1(3) and 4.93x105 M-1 (4) respectively. DNA cleavage mechanism is an oxidative DNA pathway in the presence of activators, in which giving active oxygen species such as hydroxyl radical, probably a copper-peroxide, cleaves DNA.