The current study reports the synthesis of S-2-oxo-2-phenylethyl alkylthiocarbamates 4 a-e. Bromination of acetophenone 1 with bromine in the presence of aluminium chloride gave phenacylbromide 2, which on further reaction with ammonium thiocyanate afforded the 1-phenyl-2-thiocyanatoethanone 3; treatment of 3 with appropriate alcohols in the presence sulphuric acid yielded the corresponding thiocarbamates 4 a-e. All the synthesized compounds were characterized by IR and NMR spectroscopic data.
Keywords: Alkylthiocarbamates; Synthesis; FT-IR; NMR