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Article – Journal of Advanced Chemical Sciences

Journal of Advanced Chemical Sciences, Volume 1,Issue 3,2015 Pages 86-88


The Effect of Fenofibrate Treatment on Lipid Profile
A. Ibrahim*, H.T. Sadeq, A.F. Alshanon, A.A. Hasan

Fenofibrate chemically known as 2-[4-(4-chlorobezoyl) phenoxy]-2-methylpropionic acid 1-methylethyl ester, its formula C20H21CIO4, fenofibrate is a lipophilic antihyperlipoproteinemic agent. It is a nonelectrolyte with low aqueous solubility (<3 mg/mL) and fairly high octanol/ water partition coefficient (log P 4.6). Fenofibrate is a drug of the fibrate class. It is mainly used to reduce cholesterol levels in patients at risk of cardiovascular disease. The function of fenofibrate is to reduce the production of total cholesterol, Low-Density Lipoprotein (LDL), apolipoprotein B, total triglycerides and triglyceride rich Very-Low-Density Lipoprotein (VLDL) in treated patients. Furthermore, treatment with fenofibrate results in increase in High Density Lipoprotein (HDL) and apoproteins apoAI. Fenofibrate as generic products has been very available recently to fulfill the demand of the global healthcare market.
Keywords: Fenofibrate; Docosahexaenoic acid; Eicosapentaenoic acid; Lipid profile