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Article – Journal of Advanced Chemical Sciences

Journal of Advanced Chemical Sciences, Volume 2,Issue 2,2016 Pages 261-266

Spectrophotometric Study of Osmium (VIII) Catalyzed Oxidation of Carbamazepine by Permanganate Ions in Aqueous Acidic Medium: A Kinetic and Mechanistic Approach
A. Teradale, S. Lamani, S. Das*

Oxidation kinetics of carbamazepine (CBZ) by permanganate ions in aqueous acid solutions at 25 °C at ionic strength of 0.12 mol dm-3 have been investigated by spectrophotometrically. The stoichiometry is 1:1, i.e., one mole of carbamazepine consumes one mole of permanganate ions. The order of the reaction with respect to manganese (VII) and osmium (VIII) concentration was unity while order with respect to carbamazepine was less then unity over the concentration range studied. The rate increased with an increase in acid concentration. The reaction rates revealed that the Os (VIII) catalyzed reaction was about 10-fold faster than the uncatalyzed path. A tentative mechanism consistent with the kinetics has been proposed. The reaction constants involved in the different steps of the reaction mechanism were calculated. Kinetic experiments propose that HMnO4 is the reactive permanganate species and [OsO4(OH)2]2- is the reactive Os (VIII) species.
Keywords: Carbamazepine; Osmium (VIII); Permanganate; Kinetics;