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Article – Journal of Natural Products and Resources

Journal of Natural Products and Resources, Volume 2,Issue 2,2016 Pages 62-64

Immunomodulatory Activity of Methanolic Extract of Ruta graveolens
C. Tanishq*, D. Sujata

Many herbal remedies individually or in combination have been recommended in various medical treatises for the cure of different diseases. However, the use of plant remedies, known to possess natural antioxidant, antibacterial, antiviral, immunomodulatory and many other activities, has increased in the last decade in human and animal medicine, as it is perceived as a natural approach to treat disease. Traditionally, leaves of the herb Ruta graveolens are claimed to possess immunobiological activity and hence the reason behind evaluating the immunomodulatory potential of methanolic extract of Ruta graveolens (MERG). (MERG) supposed to contain 1-Phenylnaphthalene lignans as the secondary metabolites having potent immunobiological activities. The immunomodulatory activity was evaluated by the assay of Immunoglobulin (Ig) production-stimulating activity. Oral administration of the extract significantly stimulated the Ig production at 100 mg/kg dose levels and it increases with increased concentration of the extract. The study demonstrates that Ruta graveolens can be used as a potent immunomodulator.

Keywords: Immunomodulatory Activity; Ruta graveolens; Immunoglobulin(Ig) Production;