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Article – Journal of Pharmaceutical and Medicinal Research

Journal of Pharmaceutical and Medicinal Research, Volume 2,Issue 1,2016 Pages 31-35

In Silico Analysis of HLA Polymorphism of Dengue Virus Serotypes
V. Ramesh, S. Vijayakumar*

Differences in host susceptibility to dengue infection and disease severity cannot be attributed solely to the virus virulence. On the other hand variations in immune response are often associated with polymorphism in the human genome alleles. Identified peptide vaccine candidates of E proteins of Dengue virus (DENV) serotypes were used to predict their binding abilities with 798 Human leukocyte antigen (HLA) alleles in the population and their index score was calculated. Out of 20 HLA-A alleles and 29 HLA-B alleles used for the present study, 14 alleles of HLA-A were positive indicating the resistance and only 6 of them were negative indicating susceptible nature of the alleles, and all the 29 HLA-B alleles were positive for DENV-1. The vaccine candidates of DENV-2, DENV-3 and DENV-4 also showed more positive and the resistant against dengue virus infection.

Keywords: Alleles; Dengue Serotypes; Dengue Virus; E-Proteins; Genetic Polymorphism;

Journal of Pharmaceutical and
Medicinal Research