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Article – Journal of Pharmaceutical and Medicinal Research

Journal of Pharmaceutical and Medicinal Research, Volume 3,Issue 1,2017 Pages 68-72

Studies on DNA Interaction, Biological Activities of Surfactant-Cobalt(III)-Phendione Complexes
V. Krishnaveni, N. Kumaraguru*

The mixed ligand surfactant-cobalt(III)-phendione complexes of the type cis-[Co(phendione)2(DA)Cl](ClO4)2 and cis-[Co(phendione)2(DA)2](ClO4)3 (Phendione = 1,10-Phenanthroline-5,6-dione, DA = Dodecylamine) were synthesized and characterized. The interaction between surfactant-cobalt(III)-phendione complexes and calf thymus DNA in aqueous solution was investigated by spectroscopic methods, viscosity, and electrophoresis measurements. Results suggest that the complexes bind to DNA via intercalation binding. The cytotoxicity of the surfactant-cobalt(III)-phendione complexes has been evaluated by MTT assay. Surfactant-cobalt(III)-phendione complexes were tested for antibacterial and antifungal activities having good activities.

Keywords: Surfactant; Cobalt(III); DNA Binding; Biological Studies;

Journal of Pharmaceutical and
Medicinal Research