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Article – Journal of Pharmaceutical and Medicinal Research

Journal of Pharmaceutical and Medicinal Research, Volume 1,Issue 1,2015 Pages 21-22


Biological Evaluation of Some Nitrogen Heterocyclic Compounds- Pyrrolone Derivatives
Asif Husain*

A series of 3-arylidene-5(substituted phenyl)-2(3H)-pyrrolones have been evaluated for their in vitro anthelmintic activity against two species of earthworms i.e. Pheretima posthuma and Perionyx excavatus. The anthelmintic activity of ten pyrrolones (I-X) was determined by recording the mean paralyzing and death times of the worms at concentration of 2 mg/mL. The screened compounds showed appreciable anthelmintic activities against both types of worms.


Keywords: Lactams; Pheretima posthuma; Perionyx excavates; Anthelmintic;


Journal of Pharmaceutical and
Medicinal Research