Herein, the fabrication of a cheaper modified electrode based on polyaniline and Cu composite (PANI–Cu) for the sensitive determination of Dopamine (DA) is reported. The composite formation was characterized by SEM, FT-IR, XRD and electrochemical methods. The PANI–Cu composite was used to modify Glassy carbon Electrode (GCE) and the resulting modified electrode (GCE/PANI–Cu) was used to develop a sensor for DA. The modified electrode has shown excellent electro catalytic activity to the oxidation of DA. The electrode was highly selective for DA detection. Besides, the electrode has good repeatability and reproducibility.